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apalutamide will lower the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with drugs which might be CYP3A4 substrates may lead to lessen publicity to those remedies.Co-codamol is a mix analgesic that includes a co